Multiple feature integrated transformer for E3 targeted degron prediction with protein language model

MetaDegron is a user-friendly web service for predicting E3 targeted degrons. This tool enables users to perform batch prediction of targeted degron for 21 E3 ligases, while also providing functional annotations and visualizations of various degron-related structural and physicochemical features.

Important note: Each job may take 3-5 minutes to finish. You may retrive the results anytime using the Job Identifier (JID, e.g., JOB1234_1234567890). Please do keep a record of the JID.

Example result: A quick example result page can be checked here.

Input parameters





    Check Degron(s)
    (n = 0; clear all)

    Enter protein sequence(s) in fasta format, which starts with a '>' followed with protein/peptide name.


    How to use MetaDegron for E3 targeted degron prediction

    1. Select one or more E3 ligases. The current version of MetaDegron supports 21 E3 ligase prediction.

    2. Enter protein sequence(s) in fasta format, which starts with a '>' followed with protein/peptide name.

    3. Click the Submit button.