Targeted protein degradation represents a novel but promising therapeutic modality. The interactions between E3 ubiquitin ligase and degradation signal (degron) determine the degradation specificity and maintain cellular homeostasis. Although the human genome encodes over 600 E3 ubiquitin ligases, only a small number of targeted degron instances are identified. Here, we build a user-friendly web service, named MetaDegron (Multimodal feature integrated Transformer for E3 degron) binding prediction. The built-in MetaDegron model shows excellent performance by integrating comprehensive featurization strategies and large protein language models. MetaDegron will serve the community for exploring biological mechanisms and implications of protein degradation, as well as drug discovery and design on degrons.
